6SGD

Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 24

Summary for 6SGD

• Entry DOI: 10.2210/pdb6sgd/pdb
• Descriptor: Serine/threonine-protein kinase Nek2, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: "covalent inhibitor" kinase, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33072.71

Authors

Richards, M.W.,Mas-Droux, C.P.,Bayliss, R. (deposition date: 2019-08-04, release date: 2020-06-17, Last modification date: 2024-01-24)

• Primary citation: Matheson, C.J.,Coxon, C.R.,Bayliss, R.,Boxall, K.,Carbain, B.,Fry, A.M.,Hardcastle, I.R.,Harnor, S.J.,Mas-Droux, C.,Newell, D.R.,Richards, M.W.,Sivaprakasam, M.,Turner, D.,Griffin, R.J.,Golding, B.T.,Cano, C.; 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.; Rsc Med Chem, 11:707-731, 2020; PubMed: 33479670; DOI: 10.1039/d0md00074d

Experimental method

X-RAY DIFFRACTION (2 Å)