6SGD

Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 24

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase Nek2	polymer	279	32662.5	1	UniProt (P51955) Pfam (PF00069) In PDB	Homo sapiens (Human)	HSPK 21,Never in mitosis A-related kinase 2,NimA-related protein kinase 2,NimA-like protein kinase 1
2	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
3	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	A	4-[(6-ethenyl-7~{H}-purin-2-yl)amino]benzenesulfonamide	non-polymer		316.3	1	Chemie (LD5)
5		water	water		18.0	136	Chemie (HOH)

Sequence modifications

A: 1 - 271 (UniProt: P51955)

PDB	External Database	Details
Leu 272	-	expression tag
Glu 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32662.5
Non-Polymers*	Number of molecules	4
	Total formula weight	410.2
All*	Total formula weight	33072.7

*Water molecules are not included.