6SFC
EED in complex with a methyl-thiazole
Summary for 6SFC
Entry DOI | 10.2210/pdb6sfc/pdb |
Descriptor | Polycomb protein EED, CALCIUM ION, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... (5 entities in total) |
Functional Keywords | methyltransferase eed prc2 epigenetic h3k27 wd40 inhibitor, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 85428.41 |
Authors | Read, J.A. (deposition date: 2019-08-01, release date: 2019-09-25, Last modification date: 2024-05-15) |
Primary citation | Read, J.A.,Tart, J.,Rawlins, P.B.,Gregson, C.,Jones, K.,Gao, N.,Zhu, X.,Tomlinson, R.,Code, E.,Cheung, T.,Chen, H.,Kawatkar, S.P.,Bloecher, A.,Bagal, S.,O'Donovan, D.H.,Robinson, J. Rapid Identification of Novel Allosteric PRC2 Inhibitors. Acs Chem.Biol., 14:2134-2140, 2019 Cited by PubMed: 31525019DOI: 10.1021/acschembio.9b00468 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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