6SF0

Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 2 in the presence of NADP+

Summary for 6SF0

Entry DOI	10.2210/pdb6sf0/pdb
Descriptor	Ancestral Flavin-containing monooxygenase (FMO) 2, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	flavin, enzyme, membrane protein, ancestral sequence reconstruction, oxidoreductase
Biological source	synthetic construct
Total number of polymer chains	4
Total formula weight	251302.83
Authors	Nicoll, C.,Bailleul, G.,Fiorentini, F.,Mascotti, M.L.,Fraaije, M.,Mattevi, A. (deposition date: 2019-07-30, release date: 2019-12-25, Last modification date: 2024-01-24)
Primary citation	Nicoll, C.R.,Bailleul, G.,Fiorentini, F.,Mascotti, M.L.,Fraaije, M.W.,Mattevi, A. Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nat.Struct.Mol.Biol., 27:14-24, 2020 Cited by PubMed: 31873300 DOI: 10.1038/s41594-019-0347-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.01 Å)

Structure validation