6SF0
Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 2 in the presence of NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue FAD B 601 |
| Chain | Residue |
| B | GLY9 |
| B | LEU40 |
| B | TRP41 |
| B | GLY50 |
| B | THR60 |
| B | ASN61 |
| B | THR62 |
| B | THR109 |
| B | VAL110 |
| B | CYS146 |
| B | SER147 |
| B | ALA10 |
| B | GLY148 |
| B | HIS150 |
| B | PHE337 |
| B | SER377 |
| B | ILE378 |
| B | PHE379 |
| B | NAP602 |
| B | HOH707 |
| B | GLY11 |
| B | VAL12 |
| B | SER13 |
| B | PHE31 |
| B | GLU32 |
| B | ARG33 |
| B | GLY38 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue NAP B 602 |
| Chain | Residue |
| B | TYR55 |
| B | ILE59 |
| B | ASN61 |
| B | GLY191 |
| B | ILE192 |
| B | GLY193 |
| B | ASN194 |
| B | SER195 |
| B | HIS216 |
| B | LYS280 |
| B | GLU281 |
| B | ARG302 |
| B | ALA328 |
| B | THR329 |
| B | GLY330 |
| B | GLN373 |
| B | SER423 |
| B | SER425 |
| B | FAD601 |
| B | HOH701 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | GLY9 |
| A | GLY11 |
| A | VAL12 |
| A | SER13 |
| A | PHE31 |
| A | GLU32 |
| A | ARG33 |
| A | GLY38 |
| A | GLY39 |
| A | LEU40 |
| A | TRP41 |
| A | THR60 |
| A | ASN61 |
| A | THR62 |
| A | THR109 |
| A | VAL110 |
| A | CYS146 |
| A | SER147 |
| A | GLY148 |
| A | HIS150 |
| A | PHE337 |
| A | SER377 |
| A | ILE378 |
| A | PHE379 |
| A | NAP602 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue NAP A 602 |
| Chain | Residue |
| A | TYR55 |
| A | ILE59 |
| A | THR60 |
| A | ASN61 |
| A | HIS150 |
| A | GLY191 |
| A | ILE192 |
| A | GLY193 |
| A | ASN194 |
| A | SER195 |
| A | ARG215 |
| A | HIS216 |
| A | ARG223 |
| A | GLU281 |
| A | ALA328 |
| A | THR329 |
| A | GLY330 |
| A | GLN373 |
| A | SER423 |
| A | SER425 |
| A | FAD601 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | binding site for residue FAD C 601 |
| Chain | Residue |
| C | ARG33 |
| C | GLY38 |
| C | GLY39 |
| C | LEU40 |
| C | TRP41 |
| C | THR60 |
| C | ASN61 |
| C | THR62 |
| C | THR109 |
| C | VAL110 |
| C | CYS146 |
| C | SER147 |
| C | GLY148 |
| C | HIS150 |
| C | PHE337 |
| C | SER377 |
| C | ILE378 |
| C | PHE379 |
| C | NAP602 |
| C | GLY9 |
| C | GLY11 |
| C | VAL12 |
| C | SER13 |
| C | PHE31 |
| C | GLU32 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | binding site for residue NAP C 602 |
| Chain | Residue |
| C | TYR55 |
| C | ILE59 |
| C | ASN61 |
| C | HIS150 |
| C | SER159 |
| C | ILE190 |
| C | GLY191 |
| C | ILE192 |
| C | GLY193 |
| C | ASN194 |
| C | SER195 |
| C | ASP198 |
| C | HIS216 |
| C | GLU281 |
| C | ALA328 |
| C | THR329 |
| C | GLY330 |
| C | GLN373 |
| C | SER423 |
| C | SER425 |
| C | FAD601 |
| C | HOH703 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | binding site for residue FAD D 601 |
| Chain | Residue |
| D | ILE8 |
| D | GLY9 |
| D | GLY11 |
| D | VAL12 |
| D | SER13 |
| D | PHE31 |
| D | GLU32 |
| D | ARG33 |
| D | THR34 |
| D | GLY38 |
| D | GLY39 |
| D | LEU40 |
| D | TRP41 |
| D | GLY50 |
| D | THR60 |
| D | ASN61 |
| D | THR62 |
| D | VAL110 |
| D | CYS146 |
| D | SER147 |
| D | GLY148 |
| D | HIS150 |
| D | PHE337 |
| D | SER377 |
| D | ILE378 |
| D | PHE379 |
| D | NAP602 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue NAP D 602 |
| Chain | Residue |
| D | TYR55 |
| D | ILE59 |
| D | THR60 |
| D | ASN61 |
| D | GLY191 |
| D | ILE192 |
| D | GLY193 |
| D | ASN194 |
| D | SER195 |
| D | ASP198 |
| D | HIS216 |
| D | GLU281 |
| D | ARG302 |
| D | ALA328 |
| D | THR329 |
| D | GLY330 |
| D | GLN373 |
| D | SER423 |
| D | SER425 |
| D | FAD601 |
| D | HOH701 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue MA4 D 603 |
| Chain | Residue |
| D | ASP226 |
| D | VAL234 |
| D | PHE239 |
| D | SER240 |
| D | MET255 |
| D | GLN259 |
| D | ARG262 |
