6SBV

X-ray Structure of Human LDH-A with an Allosteric Inhibitor (Compound 7)

Summary for 6SBV

• Entry DOI: 10.2210/pdb6sbv/pdb
• Related: 6SBU
• Descriptor: L-lactate dehydrogenase A chain, ~{N}-[3-[(7-nitrodibenzofuran-2-yl)sulfonylamino]phenyl]-1-oxidanyl-cyclopropane-1-carboxamide (3 entities in total)
• Functional Keywords: ldha, oxidoreductase, oxidoreductase inhibitor, allosteric inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 297023.82

Authors

Friberg, A.,Puetter, V.,Nguyen, D.,Rehwinkel, H. (deposition date: 2019-07-22, release date: 2020-06-10, Last modification date: 2024-01-24)

• Primary citation: Friberg, A.,Rehwinkel, H.,Nguyen, D.,Putter, V.,Quanz, M.,Weiske, J.,Eberspacher, U.,Heisler, I.,Langer, G.; Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A.; Acs Omega, 5:13034-13041, 2020; PubMed: 32548488; DOI: 10.1021/acsomega.0c00715

Experimental method

X-RAY DIFFRACTION (2.6 Å)