6S9B

EGFR-KINASE IN COMPLEX WITH COMPOUND 1

Summary for 6S9B

• Entry DOI: 10.2210/pdb6s9b/pdb
• Descriptor: Epidermal growth factor receptor, 3-fluoranyl-~{N}-[1-(2-methyl-2-oxidanyl-propyl)benzimidazol-2-yl]-5-pyridin-3-yl-benzamide (2 entities in total)
• Functional Keywords: egf receptor kinase mutant t790m, l858r, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37551.47

Authors

Bader, G. (deposition date: 2019-07-12, release date: 2019-11-20, Last modification date: 2019-12-04)

• Primary citation: Engelhardt, H.,Bose, D.,Petronczki, M.,Scharn, D.,Bader, G.,Baum, A.,Bergner, A.,Chong, E.,Dobel, S.,Egger, G.,Engelhardt, C.,Ettmayer, P.,Fuchs, J.E.,Gerstberger, T.,Gonnella, N.,Grimm, A.,Grondal, E.,Haddad, N.,Hopfgartner, B.,Kousek, R.,Krawiec, M.,Kriz, M.,Lamarre, L.,Leung, J.,Mayer, M.,Patel, N.D.,Simov, B.P.,Reeves, J.T.,Schnitzer, R.,Schrenk, A.,Sharps, B.,Solca, F.,Stadtmuller, H.,Tan, Z.,Wunberg, T.,Zoephel, A.,McConnell, D.B.; Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.; J.Med.Chem., 62:10272-10293, 2019; PubMed: 31689114; DOI: 10.1021/acs.jmedchem.9b01169

Experimental method

X-RAY DIFFRACTION (3.25 Å)