6S7H
Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state
Summary for 6S7H
Entry DOI | 10.2210/pdb6s7h/pdb |
Descriptor | 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | nucleotide analog, en, 5nt, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 60025.15 |
Authors | Pippel, J.,Strater, N. (deposition date: 2019-07-04, release date: 2020-07-22, Last modification date: 2024-01-24) |
Primary citation | Bhattarai, S.,Pippel, J.,Meyer, A.,Freundlieb, M.,Schmies, C.,Abdelrahman, A.,Fiene, A.,Lee, S.Y.,Zimmermann, H.,El-Tayeb, A.,Yegutkin, G.G.,Strater, N.,Muller, C.E. X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Adv Ther, 2019 Cited by DOI: 10.1002/adtp.201900075PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)