6S60

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Summary for 6S60

• Entry DOI: 10.2210/pdb6s60/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, MYRISTIC ACID, 4-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]butanoic acid, ... (4 entities in total)
• Functional Keywords: tead2, inhibitor, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 55867.23

Authors

Sturbaut, M.,Allemand, F.,Guichou, J.F. (deposition date: 2019-07-02, release date: 2020-07-22, Last modification date: 2024-01-24)

• Primary citation: Sturbaut, M.,Bailly, F.,Coevoet, M.,Sileo, P.,Pugniere, M.,Liberelle, M.,Magnez, R.,Thuru, X.,Chartier-Harlin, M.C.,Melnyk, P.,Gelin, M.,Allemand, F.,Guichou, J.F.,Cotelle, P.; Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.; Eur.J.Med.Chem., 226:113835-113835, 2021; PubMed: 34509860; DOI: 10.1016/j.ejmech.2021.113835

Experimental method

X-RAY DIFFRACTION (2 Å)