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6S60

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BTranscriptional enhancer factor TEF-4polymer24027489.12UniProt (Q15562)
Pfam (PF17725)
In PDB
Homo sapiens (Human)TEA domain family member 2,TEAD-2
2A, BMYRISTIC ACIDnon-polymer228.42Chemie (MYR)
3B4-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]butanoic acidnon-polymer432.31Chemie (KX8)
4waterwater18.0103Chemie (HOH)
Sequence modifications
A, B: 217 - 447 (UniProt: Q15562)
PDBExternal DatabaseDetails
Met 216-initiating methionine
Val 448-expression tag
Glu 449-expression tag
His 450-expression tag
His 451-expression tag
His 452-expression tag
His 453-expression tag
His 454-expression tag
His 455-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight54978.2
Non-Polymers*Number of molecules3
Total formula weight889.0
All*Total formula weight55867.2
*Water molecules are not included.

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PDB entries from 2024-06-12

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