6S5V
Crystal structure of the Cap-Midlink region of the H5N1 Influenza A virus polymerase in complex with a Cap-domain binding analogue
This is a non-PDB format compatible entry.
Summary for 6S5V
Entry DOI | 10.2210/pdb6s5v/pdb |
Descriptor | Polymerase basic protein 2, (1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | influenza a, h5n1, influenza polymerase, cap binding analogue, viral protein |
Biological source | Influenza A virus (A/duck/Fujian/13/2002(H5N1)) |
Total number of polymer chains | 2 |
Total formula weight | 70068.95 |
Authors | Keown, J.R.,Fodor, E.,Grimes, J.M. (deposition date: 2019-07-02, release date: 2019-11-06, Last modification date: 2024-05-15) |
Primary citation | McGowan, D.C.,Balemans, W.,Embrechts, W.,Motte, M.,Keown, J.R.,Buyck, C.,Corbera, J.,Funes, M.,Moreno, L.,Cooymans, L.,Tahri, A.,Eymard, J.,Stoops, B.,Strijbos, R.,Van den Berg, J.,Fodor, E.,Grimes, J.M.,Koul, A.,Jonckers, T.H.M.,Raboisson, P.,Guillemont, J. Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region. J.Med.Chem., 62:9680-9690, 2019 Cited by PubMed: 31647875DOI: 10.1021/acs.jmedchem.9b01091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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