6S55

Crystal structure of human ATAD2 bromodomain in complex with N-(4-bromo-3-((3-methylpiperidin-1-yl)sulfonyl)phenyl)-2-(2,5-dioxoimidazolidin-1-yl)acetamide

Summary for 6S55

Entry DOI	10.2210/pdb6s55/pdb
Descriptor	ATPase family AAA domain-containing protein 2, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total)
Functional Keywords	inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16243.12
Authors	Chung, C. (deposition date: 2019-06-30, release date: 2019-08-21, Last modification date: 2019-09-04)
Primary citation	Bamborough, P.,Chung, C.W.,Demont, E.H.,Bridges, A.M.,Craggs, P.D.,Dixon, D.P.,Francis, P.,Furze, R.C.,Grandi, P.,Jones, E.J.,Karamshi, B.,Locke, K.,Lucas, S.C.C.,Michon, A.M.,Mitchell, D.J.,Pogany, P.,Prinjha, R.K.,Rau, C.,Roa, A.M.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J. A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J.Med.Chem., 62:7506-7525, 2019 Cited by PubMed: 31398032 DOI: 10.1021/acs.jmedchem.9b00673 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation