6S2E

Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon

Summary for 6S2E

Entry DOI	10.2210/pdb6s2e/pdb
EMDB information	10088
Descriptor	DNA polymerase epsilon catalytic subunit A, Chromosome transmission fidelity protein 8, Chromosome transmission fidelity protein 18, ... (5 entities in total)
Functional Keywords	dna polymerase, pcna loader, protein complex, replication
Biological source	Saccharomyces cerevisiae S288C More
Total number of polymer chains	4
Total formula weight	203152.80
Authors	Grabarczyk, D.B.,Song, B. (deposition date: 2019-06-20, release date: 2020-07-08, Last modification date: 2022-12-07)
Primary citation	Stokes, K.,Winczura, A.,Song, B.,Piccoli, G.,Grabarczyk, D.B. Ctf18-RFC and DNA Pol ε form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication. Nucleic Acids Res., 48:8128-8145, 2020 Cited by PubMed: 32585006 DOI: 10.1093/nar/gkaa541 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.2 Å)

Structure validation