6S25
Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand
Summary for 6S25
Entry DOI | 10.2210/pdb6s25/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, ~{tert}-butyl ~{N}-[3-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]propyl]carbamate, ... (4 entities in total) |
Functional Keywords | bet, bromodomain, rt53, inhibitor, structural genomics, structural genomics consortium, sgc, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15838.64 |
Authors | Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (deposition date: 2019-06-20, release date: 2019-07-31, Last modification date: 2024-01-24) |
Primary citation | Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
Download full validation report