6S25

Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand

Summary for 6S25

• Entry DOI: 10.2210/pdb6s25/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, ~{tert}-butyl ~{N}-[3-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]propyl]carbamate, ... (4 entities in total)
• Functional Keywords: bet, bromodomain, rt53, inhibitor, structural genomics, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15838.64

Authors

Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (deposition date: 2019-06-20, release date: 2019-07-31, Last modification date: 2024-01-24)

• Primary citation: Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC); Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.1 Å)