Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6S25

Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand

Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH366

site_idAC2
Number of Residues8
Detailsbinding site for residue EDO A 202
ChainResidue
ALEU114
AASN117
AHOH302
AHOH378
AHOH394
AARG58
AGLN59
ALEU63

site_idAC3
Number of Residues7
Detailsbinding site for residue EDO A 203
ChainResidue
APRO56
ALYS57
ATYR98
ALYS99
ALYS102
AHOH480
AHOH491

site_idAC4
Number of Residues16
Detailsbinding site for residue KSZ A 204
ChainResidue
APRO53
ALYS57
ATRP81
APRO82
ALEU92
ALEU94
AASN117
AASN140
AASP145
AILE146
AMET149
AHOH310
AHOH323
AHOH380
AHOH483
AHOH491

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon