6S15

Pyridine derivative of the natural alkaloid Berberine as Human Telomeric G-quadruplex Binder

Summary for 6S15

• Entry DOI: 10.2210/pdb6s15/pdb
• Descriptor: DNA TAGGGTTAGGGT, POTASSIUM ION, Berberine, ... (4 entities in total)
• Functional Keywords: drug-dna complex, telomeric g-quadruplex, dna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 8080.64

Authors

Ferraroni, M.,Bazzicalupi, C.,Gratteri, P.,Papi, F. (deposition date: 2019-06-18, release date: 2020-06-03, Last modification date: 2024-01-24)

• Primary citation: Papi, F.,Bazzicalupi, C.,Ferraroni, M.,Ciolli, G.,Lombardi, P.,Khan, A.Y.,Kumar, G.S.,Gratteri, P.; Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study.; Acs Med.Chem.Lett., 11:645-650, 2020; PubMed: 32435365; DOI: 10.1021/acsmedchemlett.9b00516

Experimental method

X-RAY DIFFRACTION (1.7 Å)