6RUQ
Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution
Summary for 6RUQ
Entry DOI | 10.2210/pdb6ruq/pdb |
Related | 3KG2 5L1H |
EMDB information | 4875 4920 4921 4922 4923 4924 4925 |
Descriptor | Glutamate receptor 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | receptor negative allosteric modulator antagonist non-competitve antagonist, membrane protein |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 4 |
Total formula weight | 373084.36 |
Authors | Krintel, C.,Venskutonyte, R.,Mirza, O.A.,Gajhede, M.,Kastrup, J.S. (deposition date: 2019-05-28, release date: 2020-06-24, Last modification date: 2024-01-24) |
Primary citation | Krintel, C.,Dorosz, J.,Larsen, A.H.,Thorsen, T.S.,Venskutonyte, R.,Mirza, O.,Gajhede, M.,Boesen, T.,Kastrup, J.S. Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. Febs J., 288:995-1007, 2021 Cited by PubMed: 32543078DOI: 10.1111/febs.15455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.65 Å) |
Structure validation
Download full validation report