6RT8

Structure of catharanthine synthase - an alpha-beta hydrolase from Catharanthus roseus with a cleaviminium intermediate bound

Summary for 6RT8

Entry DOI	10.2210/pdb6rt8/pdb
Descriptor	Catharanthine synthase, 18-carboxymethoxy-cleaviminium, HEXAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	alkaloid, catharanthine, natural product, biosynthesis, alpha/beta hydrolase fold, hydrolase
Biological source	Catharanthus roseus (Madagascar periwinkle)
Total number of polymer chains	8
Total formula weight	300444.46
Authors	Caputi, L.,Franke, J.,Bussey, K.,Farrow, S.C.,Curcino Vieira, I.J.,Stevenson, C.E.M.,Lawson, D.M.,O'Connor, S.E. (deposition date: 2019-05-22, release date: 2020-03-04, Last modification date: 2024-01-24)
Primary citation	Caputi, L.,Franke, J.,Bussey, K.,Farrow, S.C.,Vieira, I.J.C.,Stevenson, C.E.M.,Lawson, D.M.,O'Connor, S.E. Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids. Nat.Chem.Biol., 16:383-386, 2020 Cited by PubMed: 32066966 DOI: 10.1038/s41589-019-0460-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation