6RT8
Structure of catharanthine synthase - an alpha-beta hydrolase from Catharanthus roseus with a cleaviminium intermediate bound
Summary for 6RT8
Entry DOI | 10.2210/pdb6rt8/pdb |
Descriptor | Catharanthine synthase, 18-carboxymethoxy-cleaviminium, HEXAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | alkaloid, catharanthine, natural product, biosynthesis, alpha/beta hydrolase fold, hydrolase |
Biological source | Catharanthus roseus (Madagascar periwinkle) |
Total number of polymer chains | 8 |
Total formula weight | 300444.46 |
Authors | Caputi, L.,Franke, J.,Bussey, K.,Farrow, S.C.,Curcino Vieira, I.J.,Stevenson, C.E.M.,Lawson, D.M.,O'Connor, S.E. (deposition date: 2019-05-22, release date: 2020-03-04, Last modification date: 2024-01-24) |
Primary citation | Caputi, L.,Franke, J.,Bussey, K.,Farrow, S.C.,Vieira, I.J.C.,Stevenson, C.E.M.,Lawson, D.M.,O'Connor, S.E. Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids. Nat.Chem.Biol., 16:383-386, 2020 Cited by PubMed: 32066966DOI: 10.1038/s41589-019-0460-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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