6RQR

Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of CFTR

Summary for 6RQR

Entry DOI	10.2210/pdb6rqr/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF1,Cystic fibrosis transmembrane conductance regulator (2 entities in total)
Functional Keywords	complex, pdz, pdz-binding motif, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	32236.28
Authors	Martin, E.R.,Ford, R.C.,Robinson, R.C. (deposition date: 2019-05-16, release date: 2020-02-05, Last modification date: 2024-01-24)
Primary citation	Martin, E.R.,Barbieri, A.,Ford, R.C.,Robinson, R.C. In vivocrystals reveal critical features of the interaction between cystic fibrosis transmembrane conductance regulator (CFTR) and the PDZ2 domain of Na+/H+exchange cofactor NHERF1. J.Biol.Chem., 295:4464-4476, 2020 Cited by PubMed: 32014995 DOI: 10.1074/jbc.RA119.012015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation