6RQR

Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of CFTR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Na(+)/H(+) exchange regulatory cofactor NHE-RF1,Cystic fibrosis transmembrane conductance regulator	polymer	144	16118.1	2	UniProt (O14745) UniProt (P13569) Pfam (PF00595) In PDB	Homo sapiens (Human)	NHERF-1,Ezrin-radixin-moesin-binding phosphoprotein 50,EBP50,Regulatory cofactor of Na(+)/H(+) exchanger,Sodium-hydrogen exchanger regulatory factor 1,Solute carrier family 9 isoform A3 regulatory factor 1,CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel
2		water	water		18.0	204	Chemie (HOH)

Sequence modifications

A, B: 150 - 269 (UniProt: O14745)

PDB	External Database	Details
Met 130	-	initiating methionine
Ala 131	-	expression tag
Glu 132	-	expression tag
Glu 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
Leu 142	-	expression tag
Glu 143	-	expression tag
Val 144	-	expression tag
Leu 145	-	expression tag
Phe 146	-	expression tag
Gln 147	-	expression tag
Gly 148	-	expression tag
Pro 149	-	expression tag

A, B: 270 - 273 (UniProt: P13569)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32236.3
All*	Total formula weight	32236.3

*Water molecules are not included.