6RPN

Structure of metallo beta lactamase VIM-2 with cyclic boronate APC308.

Summary for 6RPN

• Entry DOI: 10.2210/pdb6rpn/pdb
• Related: 5FQC
• Descriptor: Beta-lactamase VIM-2, (3~{R})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, (3~{S})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, ... (8 entities in total)
• Functional Keywords: beta lactamases, antimicrobial resistance, cyclic boronate, antimicrobial protein
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 53386.63

Authors

Parkova, A.,Lucic, A.,Brem, J.,McDonough, M.A.,Langley, G.W.,Schofield, C.J. (deposition date: 2019-05-14, release date: 2020-03-25, Last modification date: 2024-01-24)

• Primary citation: Parkova, A.,Lucic, A.,Krajnc, A.,Brem, J.,Calvopina, K.,Langley, G.W.,McDonough, M.A.,Trapencieris, P.,Schofield, C.J.; Broad Spectrum beta-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate.; Acs Infect Dis., 6:1398-1404, 2020; PubMed: 31841636; DOI: 10.1021/acsinfecdis.9b00330

Experimental method

X-RAY DIFFRACTION (1.409 Å)