Human wtSTING in complex with 3'3'-c-di-GMP

Summary for 6RM0

DescriptorStimulator of interferon protein, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) (3 entities in total)
Functional Keywordsactivator, membrane protein, immune system, receptor, protein binding
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight23879.48
Smola, M.,Boura, E. (deposition date: 2019-05-03, release date: 2019-06-19, Last modification date: 2019-09-11)
Primary citation
Smola, M.,Birkus, G.,Boura, E.
No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides.
Acta Crystallogr.,Sect.F, 75:593-598, 2019
PubMed: 31475926 (PDB entries with the same primary citation)
DOI: 10.1107/S2053230X19010999
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.301160 1.4% 10.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution