6S86

Human wtSTING in complex with 3'3'-c-di-GMP

Replaces:  6RM0

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002218	biological_process	activation of innate immune response
A	0032481	biological_process	positive regulation of type I interferon production
B	0002218	biological_process	activation of innate immune response
B	0032481	biological_process	positive regulation of type I interferon production

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	binding site for residue C2E B 401

Chain	Residue
A	TYR163
A	PRO264
A	HOH401
A	HOH402
A	HOH405
B	SER162
B	TYR163
B	GLY166
B	TYR167
B	ARG232
B	ILE235
A	GLY166
B	ARG238
B	VAL239
B	TYR240
B	SER241
B	GLU260
B	THR263
B	PRO264
B	HOH505
B	HOH507
B	HOH508
A	TYR167
A	ILE235
A	ARG238
A	TYR240
A	SER241
A	GLU260
A	THR263

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37379839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GJX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31968013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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