6RLW
Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487
This is a non-PDB format compatible entry.
Summary for 6RLW
Entry DOI | 10.2210/pdb6rlw/pdb |
Descriptor | N-glycosylase/DNA lyase, 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide (3 entities in total) |
Functional Keywords | dna repair, cancer, small molecule inhibitor, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 5 |
Total formula weight | 192315.30 |
Authors | Masuyer, G.,Stenmark, P. (deposition date: 2019-05-03, release date: 2020-07-22, Last modification date: 2024-01-24) |
Primary citation | Visnes, T.,Benitez-Buelga, C.,Cazares-Korner, A.,Sanjiv, K.,Hanna, B.M.F.,Mortusewicz, O.,Rajagopal, V.,Albers, J.J.,Hagey, D.W.,Bekkhus, T.,Eshtad, S.,Baquero, J.M.,Masuyer, G.,Wallner, O.,Muller, S.,Pham, T.,Gokturk, C.,Rasti, A.,Suman, S.,Torres-Ruiz, R.,Sarno, A.,Wiita, E.,Homan, E.J.,Karsten, S.,Marimuthu, K.,Michel, M.,Koolmeister, T.,Scobie, M.,Loseva, O.,Almlof, I.,Unterlass, J.E.,Pettke, A.,Bostrom, J.,Pandey, M.,Gad, H.,Herr, P.,Jemth, A.S.,El Andaloussi, S.,Kalderen, C.,Rodriguez-Perales, S.,Benitez, J.,Krokan, H.E.,Altun, M.,Stenmark, P.,Berglund, U.W.,Helleday, T. Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Res., 48:12234-12251, 2020 Cited by PubMed: 33211885DOI: 10.1093/nar/gkaa1048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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