6RLW

Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E (AAA, BBB, CCC, DDD, EEE)	N-glycosylase/DNA lyase	polymer	337	37921.9	5	UniProt (O15527) Pfam (PF07934) Pfam (PF00730)	Homo sapiens (Human)
2	F, G, H, I, J (AAA, BBB, CCC, DDD, EEE)	4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide	non-polymer		541.2	5	Chemie (K8Q)
3	K, L, M, N, O (AAA, BBB, CCC, DDD, EEE)	water	water		18.0	771	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD, EEE: 11 - 327 (UniProt: O15527)

PDB	External Database	Details
Met -9	-	initiating methionine
Gly -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Val 5	-	expression tag
Pro 6	-	expression tag
Arg 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
His 10	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	189609.4
Non-Polymers*	Number of molecules	5
	Total formula weight	2705.9
All*	Total formula weight	192315.3

*Water molecules are not included.