6RLW

Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
AAA	0003677	molecular_function	DNA binding
AAA	0003684	molecular_function	damaged DNA binding
AAA	0003824	molecular_function	catalytic activity
AAA	0004519	molecular_function	endonuclease activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0005829	cellular_component	cytosol
AAA	0006281	biological_process	DNA repair
AAA	0006284	biological_process	base-excision repair
AAA	0006285	biological_process	base-excision repair, AP site formation
AAA	0006289	biological_process	nucleotide-excision repair
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006974	biological_process	DNA damage response
AAA	0006979	biological_process	response to oxidative stress
AAA	0008017	molecular_function	microtubule binding
AAA	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
AAA	0009314	biological_process	response to radiation
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0009416	biological_process	response to light stimulus
AAA	0016363	cellular_component	nuclear matrix
AAA	0016607	cellular_component	nuclear speck
AAA	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
AAA	0016829	molecular_function	lyase activity
AAA	0019104	molecular_function	DNA N-glycosylase activity
AAA	0019899	molecular_function	enzyme binding
AAA	0032355	biological_process	response to estradiol
AAA	0032357	molecular_function	oxidized purine DNA binding
AAA	0032991	cellular_component	protein-containing complex
AAA	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
AAA	0034614	biological_process	cellular response to reactive oxygen species
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
AAA	0045007	biological_process	depurination
AAA	0045008	biological_process	depyrimidination
AAA	0045471	biological_process	response to ethanol
AAA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
AAA	0051593	biological_process	response to folic acid
AAA	0071276	biological_process	cellular response to cadmium ion
AAA	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AAA	0140097	molecular_function	catalytic activity, acting on DNA
AAA	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
BBB	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
BBB	0003677	molecular_function	DNA binding
BBB	0003684	molecular_function	damaged DNA binding
BBB	0003824	molecular_function	catalytic activity
BBB	0004519	molecular_function	endonuclease activity
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0005829	cellular_component	cytosol
BBB	0006281	biological_process	DNA repair
BBB	0006284	biological_process	base-excision repair
BBB	0006285	biological_process	base-excision repair, AP site formation
BBB	0006289	biological_process	nucleotide-excision repair
BBB	0006355	biological_process	regulation of DNA-templated transcription
BBB	0006974	biological_process	DNA damage response
BBB	0006979	biological_process	response to oxidative stress
BBB	0008017	molecular_function	microtubule binding
BBB	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
BBB	0009314	biological_process	response to radiation
BBB	0009410	biological_process	response to xenobiotic stimulus
BBB	0009416	biological_process	response to light stimulus
BBB	0016363	cellular_component	nuclear matrix
BBB	0016607	cellular_component	nuclear speck
BBB	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
BBB	0016829	molecular_function	lyase activity
BBB	0019104	molecular_function	DNA N-glycosylase activity
BBB	0019899	molecular_function	enzyme binding
BBB	0032355	biological_process	response to estradiol
BBB	0032357	molecular_function	oxidized purine DNA binding
BBB	0032991	cellular_component	protein-containing complex
BBB	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
BBB	0034614	biological_process	cellular response to reactive oxygen species
BBB	0043066	biological_process	negative regulation of apoptotic process
BBB	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
BBB	0045007	biological_process	depurination
BBB	0045008	biological_process	depyrimidination
BBB	0045471	biological_process	response to ethanol
BBB	0045944	biological_process	positive regulation of transcription by RNA polymerase II
BBB	0051593	biological_process	response to folic acid
BBB	0071276	biological_process	cellular response to cadmium ion
BBB	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBB	0140097	molecular_function	catalytic activity, acting on DNA
BBB	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
CCC	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
CCC	0003677	molecular_function	DNA binding
CCC	0003684	molecular_function	damaged DNA binding
CCC	0003824	molecular_function	catalytic activity
CCC	0004519	molecular_function	endonuclease activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0005829	cellular_component	cytosol
CCC	0006281	biological_process	DNA repair
CCC	0006284	biological_process	base-excision repair
CCC	0006285	biological_process	base-excision repair, AP site formation
CCC	0006289	biological_process	nucleotide-excision repair
CCC	0006355	biological_process	regulation of DNA-templated transcription
CCC	0006974	biological_process	DNA damage response
CCC	0006979	biological_process	response to oxidative stress
CCC	0008017	molecular_function	microtubule binding
CCC	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
CCC	0009314	biological_process	response to radiation
CCC	0009410	biological_process	response to xenobiotic stimulus
CCC	0009416	biological_process	response to light stimulus
CCC	0016363	cellular_component	nuclear matrix
CCC	0016607	cellular_component	nuclear speck
CCC	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
CCC	0016829	molecular_function	lyase activity
CCC	0019104	molecular_function	DNA N-glycosylase activity
CCC	0019899	molecular_function	enzyme binding
CCC	0032355	biological_process	response to estradiol
CCC	0032357	molecular_function	oxidized purine DNA binding
CCC	0032991	cellular_component	protein-containing complex
CCC	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
CCC	0034614	biological_process	cellular response to reactive oxygen species
CCC	0043066	biological_process	negative regulation of apoptotic process
CCC	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
CCC	0045007	biological_process	depurination
CCC	0045008	biological_process	depyrimidination
CCC	0045471	biological_process	response to ethanol
CCC	0045944	biological_process	positive regulation of transcription by RNA polymerase II
CCC	0051593	biological_process	response to folic acid
CCC	0071276	biological_process	cellular response to cadmium ion
CCC	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CCC	0140097	molecular_function	catalytic activity, acting on DNA
CCC	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
DDD	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
DDD	0003677	molecular_function	DNA binding
DDD	0003684	molecular_function	damaged DNA binding
DDD	0003824	molecular_function	catalytic activity
DDD	0004519	molecular_function	endonuclease activity
DDD	0005515	molecular_function	protein binding
DDD	0005634	cellular_component	nucleus
DDD	0005654	cellular_component	nucleoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005759	cellular_component	mitochondrial matrix
DDD	0005829	cellular_component	cytosol
DDD	0006281	biological_process	DNA repair
DDD	0006284	biological_process	base-excision repair
DDD	0006285	biological_process	base-excision repair, AP site formation
DDD	0006289	biological_process	nucleotide-excision repair
DDD	0006355	biological_process	regulation of DNA-templated transcription
DDD	0006974	biological_process	DNA damage response
DDD	0006979	biological_process	response to oxidative stress
DDD	0008017	molecular_function	microtubule binding
DDD	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
DDD	0009314	biological_process	response to radiation
DDD	0009410	biological_process	response to xenobiotic stimulus
DDD	0009416	biological_process	response to light stimulus
DDD	0016363	cellular_component	nuclear matrix
DDD	0016607	cellular_component	nuclear speck
DDD	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
DDD	0016829	molecular_function	lyase activity
DDD	0019104	molecular_function	DNA N-glycosylase activity
DDD	0019899	molecular_function	enzyme binding
DDD	0032355	biological_process	response to estradiol
DDD	0032357	molecular_function	oxidized purine DNA binding
DDD	0032991	cellular_component	protein-containing complex
DDD	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DDD	0034614	biological_process	cellular response to reactive oxygen species
DDD	0043066	biological_process	negative regulation of apoptotic process
DDD	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
DDD	0045007	biological_process	depurination
DDD	0045008	biological_process	depyrimidination
DDD	0045471	biological_process	response to ethanol
DDD	0045944	biological_process	positive regulation of transcription by RNA polymerase II
DDD	0051593	biological_process	response to folic acid
DDD	0071276	biological_process	cellular response to cadmium ion
DDD	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDD	0140097	molecular_function	catalytic activity, acting on DNA
DDD	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
EEE	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
EEE	0003677	molecular_function	DNA binding
EEE	0003684	molecular_function	damaged DNA binding
EEE	0003824	molecular_function	catalytic activity
EEE	0004519	molecular_function	endonuclease activity
EEE	0005515	molecular_function	protein binding
EEE	0005634	cellular_component	nucleus
EEE	0005654	cellular_component	nucleoplasm
EEE	0005739	cellular_component	mitochondrion
EEE	0005759	cellular_component	mitochondrial matrix
EEE	0005829	cellular_component	cytosol
EEE	0006281	biological_process	DNA repair
EEE	0006284	biological_process	base-excision repair
EEE	0006285	biological_process	base-excision repair, AP site formation
EEE	0006289	biological_process	nucleotide-excision repair
EEE	0006355	biological_process	regulation of DNA-templated transcription
EEE	0006974	biological_process	DNA damage response
EEE	0006979	biological_process	response to oxidative stress
EEE	0008017	molecular_function	microtubule binding
EEE	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
EEE	0009314	biological_process	response to radiation
EEE	0009410	biological_process	response to xenobiotic stimulus
EEE	0009416	biological_process	response to light stimulus
EEE	0016363	cellular_component	nuclear matrix
EEE	0016607	cellular_component	nuclear speck
EEE	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
EEE	0016829	molecular_function	lyase activity
EEE	0019104	molecular_function	DNA N-glycosylase activity
EEE	0019899	molecular_function	enzyme binding
EEE	0032355	biological_process	response to estradiol
EEE	0032357	molecular_function	oxidized purine DNA binding
EEE	0032991	cellular_component	protein-containing complex
EEE	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
EEE	0034614	biological_process	cellular response to reactive oxygen species
EEE	0043066	biological_process	negative regulation of apoptotic process
EEE	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
EEE	0045007	biological_process	depurination
EEE	0045008	biological_process	depyrimidination
EEE	0045471	biological_process	response to ethanol
EEE	0045944	biological_process	positive regulation of transcription by RNA polymerase II
EEE	0051593	biological_process	response to folic acid
EEE	0071276	biological_process	cellular response to cadmium ion
EEE	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EEE	0140097	molecular_function	catalytic activity, acting on DNA
EEE	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:9197244

Chain	Residue	Details
AAA	LYS249
BBB	LYS249
CCC	LYS249
DDD	LYS249
EEE	LYS249

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	BINDING: BINDING => ECO:0000269|PubMed:10706276, ECO:0000269|PubMed:11902834, ECO:0000269|PubMed:12578369, ECO:0000269|PubMed:12592398, ECO:0000269|PubMed:15610848

Chain	Residue	Details
AAA	ASN149
BBB	GLN287
CCC	ASN149
CCC	ARG154
CCC	ARG204
CCC	HIS270
CCC	GLN287
DDD	ASN149
DDD	ARG154
DDD	ARG204
DDD	HIS270
AAA	ARG154
DDD	GLN287
EEE	ASN149
EEE	ARG154
EEE	ARG204
EEE	HIS270
EEE	GLN287
AAA	ARG204
AAA	HIS270
AAA	GLN287
BBB	ASN149
BBB	ARG154
BBB	ARG204
BBB	HIS270

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
AAA	PRO266
CCC	ASP268
CCC	GLN315
CCC	PHE319
DDD	PRO266
DDD	ASP268
DDD	GLN315
DDD	PHE319
EEE	PRO266
EEE	ASP268
EEE	GLN315
AAA	ASP268
EEE	PHE319
AAA	GLN315
AAA	PHE319
BBB	PRO266
BBB	ASP268
BBB	GLN315
BBB	PHE319
CCC	PRO266

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 185

Chain	Residue	Details
AAA	LYS249	covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
AAA	ASP268	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 185

Chain	Residue	Details
BBB	LYS249	covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
BBB	ASP268	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 185

Chain	Residue	Details
CCC	LYS249	covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
CCC	ASP268	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 185

Chain	Residue	Details
DDD	LYS249	covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
DDD	ASP268	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA5
Number of Residues	2
Details	M-CSA 185

Chain	Residue	Details
EEE	LYS249	covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
EEE	ASP268	electrostatic stabiliser, hydrogen bond acceptor

---