6RLC

Crystal structure of the PDZ tandem of syntenin in complex with fragment F13

6RLC の概要

• エントリーDOI: 10.2210/pdb6rlc/pdb
• 分子名称: Syntenin-1, (2~{S})-2-[3-(4-chlorophenyl)sulfanylpropanoylamino]-3-methyl-butanoic acid, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: signaling protein cell adhesion pdz domain syntenin syndecan drug design, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 73515.15

構造登録者

Feracci, M.,Barral, K. (登録日: 2019-05-02, 公開日: 2021-02-03, 最終更新日: 2024-05-15)

• 主引用文献: Leblanc, R.,Kashyap, R.,Barral, K.,Egea-Jimenez, A.L.,Kovalskyy, D.,Feracci, M.,Garcia, M.,Derviaux, C.,Betzi, S.,Ghossoub, R.,Platonov, M.,Roche, P.,Morelli, X.,Hoffer, L.,Zimmermann, P.; Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo.; J Extracell Vesicles, 10:e12039-e12039, 2020; PubMed: 33343836; DOI: 10.1002/jev2.12039

実験手法

X-RAY DIFFRACTION (2.2 Å)