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6RKP

Crystal structure of human monoamine oxidase B in complex with styrylpiperidine analogue 84

Summary for 6RKP
Entry DOI10.2210/pdb6rkp/pdb
DescriptorAmine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 1-[(~{E})-prop-1-enyl]-4-[(~{E})-2-[4-(trifluoromethyl)phenyl]ethenyl]piperidine, ... (6 entities in total)
Functional Keywordsmonoamine oxidase, drug target, neurodegeneration, flavin, isomer, mitochondrial membrane, flavoprotein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight120694.54
Authors
Iacovino, L.G.,Knez, D.,Colettis, N.,Sova, M.,Pislar, A.,Higgs, J.,Kamecki, F.,Mangialavori, I.,Dolsak, A.,Zakelj, S.,Trontelj, J.,Kos, J.,Marder, N.M.,Gobec, S.,Binda, C. (deposition date: 2019-04-30, release date: 2020-01-29, Last modification date: 2024-01-24)
Primary citationKnez, D.,Colettis, N.,Iacovino, L.G.,Sova, M.,Pislar, A.,Konc, J.,Lesnik, S.,Higgs, J.,Kamecki, F.,Mangialavori, I.,Dolsak, A.,Zakelj, S.,Trontelj, J.,Kos, J.,Binda, C.,Marder, M.,Gobec, S.
Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B.
J.Med.Chem., 63:1361-1387, 2020
Cited by
PubMed: 31917923
DOI: 10.1021/acs.jmedchem.9b01886
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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