6RKP
Crystal structure of human monoamine oxidase B in complex with styrylpiperidine analogue 84
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005740 | cellular_component | mitochondrial envelope |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0008131 | molecular_function | primary amine oxidase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0010044 | biological_process | response to aluminum ion |
| A | 0010269 | biological_process | response to selenium ion |
| A | 0014063 | biological_process | negative regulation of serotonin secretion |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019607 | biological_process | phenylethylamine catabolic process |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0030425 | cellular_component | dendrite |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0042420 | biological_process | dopamine catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045471 | biological_process | response to ethanol |
| A | 0045964 | biological_process | positive regulation of dopamine metabolic process |
| A | 0048545 | biological_process | response to steroid hormone |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
| A | 0051412 | biological_process | response to corticosterone |
| A | 0052595 | molecular_function | aliphatic amine oxidase activity |
| A | 0097621 | molecular_function | monoamine oxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005740 | cellular_component | mitochondrial envelope |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0008131 | molecular_function | primary amine oxidase activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0010044 | biological_process | response to aluminum ion |
| B | 0010269 | biological_process | response to selenium ion |
| B | 0014063 | biological_process | negative regulation of serotonin secretion |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019607 | biological_process | phenylethylamine catabolic process |
| B | 0021762 | biological_process | substantia nigra development |
| B | 0030425 | cellular_component | dendrite |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0042420 | biological_process | dopamine catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0045471 | biological_process | response to ethanol |
| B | 0045964 | biological_process | positive regulation of dopamine metabolic process |
| B | 0048545 | biological_process | response to steroid hormone |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
| B | 0051412 | biological_process | response to corticosterone |
| B | 0052595 | molecular_function | aliphatic amine oxidase activity |
| B | 0097621 | molecular_function | monoamine oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue C15 A 602 |
| Chain | Residue |
| A | ASP153 |
| A | LYS154 |
| A | CYS156 |
| A | HOH748 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | HOH710 |
| A | HOH721 |
| A | HIS91 |
| A | GLY94 |
| A | GLU321 |
| A | LYS370 |
| A | HOH705 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue C15 B 602 |
| Chain | Residue |
| B | ASP153 |
| B | LYS154 |
| B | CYS156 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | HIS91 |
| B | GLY94 |
| B | ALA322 |
| B | HOH720 |
| B | HOH726 |
| B | HOH799 |
| B | HOH844 |
| site_id | AC5 |
| Number of Residues | 45 |
| Details | binding site for residues FAD A 600 and G94 A 601 |
| Chain | Residue |
| A | GLY11 |
| A | GLY13 |
| A | ILE14 |
| A | SER15 |
| A | LEU33 |
| A | GLU34 |
| A | ALA35 |
| A | ARG36 |
| A | GLY40 |
| A | GLY41 |
| A | ARG42 |
| A | THR43 |
| A | GLY58 |
| A | SER59 |
| A | TYR60 |
| A | PRO104 |
| A | TRP119 |
| A | LEU164 |
| A | LEU171 |
| A | ILE199 |
| A | GLN206 |
| A | PRO234 |
| A | VAL235 |
| A | ALA263 |
| A | ILE264 |
| A | ILE316 |
| A | PHE343 |
| A | TRP388 |
| A | TYR393 |
| A | CYS397 |
| A | TYR398 |
| A | GLY425 |
| A | THR426 |
| A | GLY434 |
| A | TYR435 |
| A | MET436 |
| A | ALA439 |
| A | HOH752 |
| A | HOH778 |
| A | HOH791 |
| A | HOH814 |
| A | HOH831 |
| A | HOH878 |
| A | HOH898 |
| A | HOH955 |
| site_id | AC6 |
| Number of Residues | 46 |
| Details | binding site for residues FAD B 600 and G94 B 601 |
| Chain | Residue |
| B | THR426 |
| B | GLY434 |
| B | TYR435 |
| B | MET436 |
| B | ALA439 |
| B | HOH743 |
| B | HOH766 |
| B | HOH779 |
| B | HOH810 |
| B | HOH823 |
| B | HOH906 |
| B | HOH991 |
| B | HOH1011 |
| B | GLY11 |
| B | GLY13 |
| B | ILE14 |
| B | SER15 |
| B | LEU33 |
| B | GLU34 |
| B | ALA35 |
| B | ARG36 |
| B | GLY40 |
| B | GLY41 |
| B | ARG42 |
| B | THR43 |
| B | GLY58 |
| B | SER59 |
| B | TYR60 |
| B | PRO104 |
| B | TRP119 |
| B | LEU164 |
| B | LEU171 |
| B | ILE199 |
| B | GLN206 |
| B | PRO234 |
| B | VAL235 |
| B | ALA263 |
| B | ILE264 |
| B | ILE316 |
| B | TYR326 |
| B | PHE343 |
| B | TRP388 |
| B | TYR393 |
| B | CYS397 |
| B | TYR398 |
| B | GLY425 |
| site_id | AC7 |
| Number of Residues | 43 |
| Details | binding site for Di-peptide FAD B 600 and CYS B 397 |
| Chain | Residue |
| B | GLY11 |
| B | GLY13 |
| B | ILE14 |
| B | SER15 |
| B | LEU33 |
| B | GLU34 |
| B | ALA35 |
| B | ARG36 |
| B | GLY40 |
| B | GLY41 |
| B | ARG42 |
| B | THR43 |
| B | GLY58 |
| B | SER59 |
| B | TYR60 |
| B | THR174 |
| B | PRO234 |
| B | VAL235 |
| B | ALA263 |
| B | ILE264 |
| B | GLY292 |
| B | SER293 |
| B | VAL294 |
| B | TRP388 |
| B | TYR393 |
| B | GLY396 |
| B | TYR398 |
| B | THR399 |
| B | GLY425 |
| B | THR426 |
| B | GLY434 |
| B | TYR435 |
| B | MET436 |
| B | ALA439 |
| B | K72601 |
| B | HOH743 |
| B | HOH766 |
| B | HOH779 |
| B | HOH810 |
| B | HOH823 |
| B | HOH906 |
| B | HOH991 |
| B | HOH1011 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 974 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | SER2-VAL489 | |
| B | SER2-VAL489 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Anchor for type IV membrane protein |
| Chain | Residue | Details |
| A | PRO490-LEU516 | |
| B | PRO490-LEU516 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Mitochondrial intermembrane |
| Chain | Residue | Details |
| A | LEU517-VAL520 | |
| B | LEU517-VAL520 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Important for catalytic activity |
| Chain | Residue | Details |
| A | CYS156 | |
| A | CYS365 | |
| A | HIS382 | |
| B | CYS156 | |
| B | CYS365 | |
| B | HIS382 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:11049757 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BW75 |
| Chain | Residue | Details |
| A | LYS52 | |
| B | LYS52 |
| Chain | Residue | Details |
| A | CYS397 | |
| B | CYS397 |
