6RKB

Crystal structure of human monoamine oxidase B in complex with styrylpiperidine analogue 1

Summary for 6RKB

• Entry DOI: 10.2210/pdb6rkb/pdb
• Descriptor: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 4-[(~{E})-2-(4-fluorophenyl)ethenyl]-1-[(~{E})-prop-1-enyl]piperidine, ... (5 entities in total)
• Functional Keywords: monoamine oxidase, drug target, neurodegeneration, flavin, isomer, mitochondrial membrane, flavoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 120410.34

Authors

Iacovino, L.G.,Knez, D.,Colettis, N.,Sova, M.,Pislar, A.,Higgs, J.,Kamecki, F.,Mangialavori, I.,Dolsak, A.,Zakelj, S.,Trontelj, J.,Kos, J.,Marder, N.M.,Gobec, S.,Binda, C. (deposition date: 2019-04-30, release date: 2020-01-29, Last modification date: 2024-01-24)

• Primary citation: Knez, D.,Colettis, N.,Iacovino, L.G.,Sova, M.,Pislar, A.,Konc, J.,Lesnik, S.,Higgs, J.,Kamecki, F.,Mangialavori, I.,Dolsak, A.,Zakelj, S.,Trontelj, J.,Kos, J.,Binda, C.,Marder, M.,Gobec, S.; Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B.; J.Med.Chem., 63:1361-1387, 2020; PubMed: 31917923; DOI: 10.1021/acs.jmedchem.9b01886

Experimental method

X-RAY DIFFRACTION (2.3 Å)