6RKB
Crystal structure of human monoamine oxidase B in complex with styrylpiperidine analogue 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005740 | cellular_component | mitochondrial envelope |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0008131 | molecular_function | primary methylamine oxidase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0042420 | biological_process | dopamine catabolic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
| A | 0097621 | molecular_function | monoamine oxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005740 | cellular_component | mitochondrial envelope |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0008131 | molecular_function | primary methylamine oxidase activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0021762 | biological_process | substantia nigra development |
| B | 0042420 | biological_process | dopamine catabolic process |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
| B | 0097621 | molecular_function | monoamine oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue C15 A 603 |
| Chain | Residue |
| A | ASP153 |
| A | LYS154 |
| A | CYS156 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue C15 B 603 |
| Chain | Residue |
| B | ASP153 |
| B | LYS154 |
| site_id | AC3 |
| Number of Residues | 40 |
| Details | binding site for residues FAD A 601 and K6Q A 602 |
| Chain | Residue |
| A | LEU33 |
| A | GLU34 |
| A | ALA35 |
| A | ARG36 |
| A | GLY40 |
| A | GLY41 |
| A | ARG42 |
| A | THR43 |
| A | GLY57 |
| A | GLY58 |
| A | SER59 |
| A | TYR60 |
| A | LEU171 |
| A | ILE199 |
| A | GLN206 |
| A | PRO234 |
| A | VAL235 |
| A | ALA263 |
| A | ILE264 |
| A | TYR326 |
| A | PHE343 |
| A | TRP388 |
| A | TYR393 |
| A | CYS397 |
| A | TYR398 |
| A | GLY425 |
| A | THR426 |
| A | GLY434 |
| A | TYR435 |
| A | MET436 |
| A | HOH717 |
| A | HOH722 |
| A | HOH732 |
| A | HOH734 |
| A | HOH758 |
| A | HOH784 |
| A | GLY11 |
| A | GLY13 |
| A | ILE14 |
| A | SER15 |
| site_id | AC4 |
| Number of Residues | 43 |
| Details | binding site for residues FAD B 601 and K6Q B 602 |
| Chain | Residue |
| B | VAL10 |
| B | GLY11 |
| B | GLY13 |
| B | ILE14 |
| B | SER15 |
| B | LEU33 |
| B | GLU34 |
| B | ALA35 |
| B | ARG36 |
| B | GLY40 |
| B | GLY41 |
| B | ARG42 |
| B | THR43 |
| B | GLY57 |
| B | GLY58 |
| B | SER59 |
| B | TYR60 |
| B | LEU171 |
| B | ILE199 |
| B | GLN206 |
| B | PRO234 |
| B | VAL235 |
| B | ALA263 |
| B | ILE264 |
| B | TYR326 |
| B | TRP388 |
| B | TYR393 |
| B | CYS397 |
| B | TYR398 |
| B | GLY425 |
| B | THR426 |
| B | GLY434 |
| B | TYR435 |
| B | MET436 |
| B | ALA439 |
| B | HOH743 |
| B | HOH756 |
| B | HOH763 |
| B | HOH764 |
| B | HOH771 |
| B | HOH790 |
| B | HOH826 |
| B | HOH895 |
| site_id | AC5 |
| Number of Residues | 45 |
| Details | binding site for Di-peptide FAD B 601 and CYS B 397 |
| Chain | Residue |
| B | ARG42 |
| B | THR43 |
| B | GLY57 |
| B | GLY58 |
| B | SER59 |
| B | TYR60 |
| B | THR174 |
| B | PRO234 |
| B | VAL235 |
| B | ALA263 |
| B | ILE264 |
| B | GLY292 |
| B | SER293 |
| B | VAL294 |
| B | TRP388 |
| B | TYR393 |
| B | GLY396 |
| B | TYR398 |
| B | THR399 |
| B | GLY425 |
| B | THR426 |
| B | GLY434 |
| B | TYR435 |
| B | MET436 |
| B | ALA439 |
| B | K6Q602 |
| B | HOH743 |
| B | HOH756 |
| B | HOH763 |
| B | HOH764 |
| B | HOH771 |
| B | HOH790 |
| B | HOH826 |
| B | HOH895 |
| B | VAL10 |
| B | GLY11 |
| B | GLY13 |
| B | ILE14 |
| B | SER15 |
| B | LEU33 |
| B | GLU34 |
| B | ALA35 |
| B | ARG36 |
| B | GLY40 |
| B | GLY41 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 974 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | SER2-VAL489 | |
| B | SER2-VAL489 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Anchor for type IV membrane protein |
| Chain | Residue | Details |
| A | PRO490-LEU516 | |
| B | PRO490-LEU516 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Mitochondrial intermembrane |
| Chain | Residue | Details |
| A | LEU517-VAL520 | |
| B | LEU517-VAL520 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Important for catalytic activity |
| Chain | Residue | Details |
| A | CYS156 | |
| A | CYS365 | |
| A | HIS382 | |
| B | CYS156 | |
| B | CYS365 | |
| B | HIS382 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:11049757 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BW75 |
| Chain | Residue | Details |
| A | LYS52 | |
| B | LYS52 |
| Chain | Residue | Details |
| A | CYS397 | |
| B | CYS397 |
