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6RGK

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-055

Summary for 6RGK
Entry DOI10.2210/pdb6rgk/pdb
Related6GXQ 6HWO 6RB6 6RCW 6RFN 6RFW
DescriptorPhosphodiesterase, ZINC ION, MAGNESIUM ION, ... (8 entities in total)
Functional Keywordsparasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness
Biological sourceTrypanosoma brucei
Total number of polymer chains2
Total formula weight82999.04
Authors
Singh, A.K.,Brown, D.G. (deposition date: 2019-04-16, release date: 2019-07-24, Last modification date: 2024-01-24)
Primary citationde Heuvel, E.,Singh, A.K.,Boronat, P.,Kooistra, A.J.,van der Meer, T.,Sadek, P.,Blaazer, A.R.,Shaner, N.C.,Bindels, D.S.,Caljon, G.,Maes, L.,Sterk, G.J.,Siderius, M.,Oberholzer, M.,de Esch, I.J.P.,Brown, D.G.,Leurs, R.
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
Bioorg.Med.Chem., 27:4013-4029, 2019
Cited by
PubMed: 31378593
DOI: 10.1016/j.bmc.2019.06.026
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

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