6RG4
Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzyl-4-methylpiperazin-1-yl)benzenesulfonamide
Summary for 6RG4
| Entry DOI | 10.2210/pdb6rg4/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29912.13 |
| Authors | Ferraroni, M.,Angeli, A.,Supuran, C. (deposition date: 2019-04-16, release date: 2020-05-13, Last modification date: 2024-01-24) |
| Primary citation | Chiaramonte, N.,Bua, S.,Angeli, A.,Ferraroni, M.,Picchioni, I.,Bartolucci, G.,Braconi, L.,Dei, S.,Teodori, E.,Supuran, C.T.,Romanelli, M.N. Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors. Bioorg.Chem., 91:103130-103130, 2019 Cited by PubMed: 31374520DOI: 10.1016/j.bioorg.2019.103130 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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