6RFI

IRAK4 IN COMPLEX WITH inhibitor

Summary for 6RFI

Entry DOI	10.2210/pdb6rfi/pdb
Descriptor	Interleukin-1 receptor-associated kinase 4, SULFATE ION, methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate, ... (4 entities in total)
Functional Keywords	irak4, kinase, inhibitor, cancer, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	74037.23
Authors	Xue, Y.,Degorce, S.L.,Robb, G.R.,Ferguson, A.D. (deposition date: 2019-04-15, release date: 2019-10-30, Last modification date: 2019-11-27)
Primary citation	Degorce, S.L.,Anjum, R.,Bloecher, A.,Carbajo, R.J.,Dillman, K.S.,Drew, L.,Halsall, C.T.,Lenz, E.M.,Lindsay, N.A.,Mayo, M.F.,Pink, J.H.,Robb, G.R.,Rosen, A.,Scott, J.S.,Xue, Y. Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265PMutant Diffuse Large B Cell Lymphoma. J.Med.Chem., 62:9918-9930, 2019 Cited by PubMed: 31622099 DOI: 10.1021/acs.jmedchem.9b01346 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation