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6RFI

IRAK4 IN COMPLEX WITH inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
B0000287molecular_functionmagnesium ion binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SO4 A 501
ChainResidue
APHE165
APHE165
AHIS166
AHIS166
ASER167
ASER167

site_idAC2
Number of Residues13
Detailsbinding site for residue K1H A 502
ChainResidue
AALA211
ALYS213
ATYR262
AVAL263
ATYR264
AMET265
AASP272
ALEU277
ALEU318
AHOH620
AMET192
AGLY193
AGLU194

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 B 501
ChainResidue
AASP422
ASER423
BLYS174
BASN207

site_idAC4
Number of Residues13
Detailsbinding site for residue K1H B 502
ChainResidue
BMET192
BGLY193
BGLU194
BVAL200
BALA211
BLYS213
BTYR262
BVAL263
BMET265
BASP272
BLEU318
BHOH605
BHOH646

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AASP311
BASP311

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AMET192
BMET192

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING:
ChainResidueDetails
ALYS213
ALYS313
AASP329
BLYS213
BLYS313
BASP329

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32
ChainResidueDetails
ATHR342
BTHR342

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32
ChainResidueDetails
ATPO345
BTPO345

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103
ChainResidueDetails
ASEP346
BSEP346

226707

PDB entries from 2024-10-30

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