6RA4
Human ARGONAUTE-2 PAZ DOMAIN (214-347) IN COMPLEX WITH CGUGACUCU
Summary for 6RA4
Entry DOI | 10.2210/pdb6ra4/pdb |
Descriptor | Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3'), GLYCEROL, ... (4 entities in total) |
Functional Keywords | sirna, paz domain, rna binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 37436.45 |
Authors | Rondeau, J.-M.,Bourgier, E. (deposition date: 2019-04-05, release date: 2019-05-08, Last modification date: 2024-05-15) |
Primary citation | Greenidge, P.A.,Blommers, M.J.J.,Priestle, J.P.,Hunziker, J. How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection. J.Chem.Inf.Model., 59:1897-1908, 2019 Cited by PubMed: 31021613DOI: 10.1021/acs.jcim.8b00892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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