6R8X
COAGULATION FACTOR XI CATALYTIC DOMAIN IN COMPLEX WITH FAB-PORTION OF MAA868
Summary for 6R8X
Entry DOI | 10.2210/pdb6r8x/pdb |
Descriptor | Coagulation factor XI, anti-Factor-XI Fab fragment light chain MAA868, anti-Factor-XI Fab fragment heavy chain MAA868, ... (4 entities in total) |
Functional Keywords | coagulation fxi, zymogen, antibody, antagonist, blood clotting |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 74741.64 |
Authors | Schiering, N.,Koch, A. (deposition date: 2019-04-02, release date: 2019-04-10, Last modification date: 2024-05-01) |
Primary citation | Koch, A.W.,Schiering, N.,Melkko, S.,Ewert, S.,Salter, J.,Zhang, Y.,McCormack, P.,Yu, J.,Huang, X.,Chiu, Y.H.,Chen, Z.,Schleeger, S.,Horny, G.,DiPetrillo, K.,Muller, L.,Hein, A.,Villard, F.,Scharenberg, M.,Ramage, P.,Hassiepen, U.,Cote, S.,DeGagne, J.,Krantz, C.,Eder, J.,Stoll, B.,Kulmatycki, K.,Feldman, D.L.,Hoffmann, P.,Basson, C.T.,Frost, R.J.A.,Khder, Y. MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans. Blood, 133:1507-1516, 2019 Cited by PubMed: 30692123DOI: 10.1182/blood-2018-10-880849 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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