6R8G
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine
Summary for 6R8G
Entry DOI | 10.2210/pdb6r8g/pdb |
Related | 5nfr |
Descriptor | Malate dehydrogenase, 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, SODIUM ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 4 |
Total formula weight | 142986.98 |
Authors | Romero, A.R.,Calderone, V.,Gentili, M.,Lunev, S.,Groves, M.,Popowicz, G.,Domling, A.,Sattler, M. (deposition date: 2019-04-01, release date: 2020-04-15, Last modification date: 2024-01-24) |
Primary citation | Romero, A.R.,Lunev, S.,Popowicz, G.,Calderone, V.,Gentili, M.,Sattler, M.,Plewka, J.,Taube, M.,Kozak, M.,Holak, T.A.,Domling, A.,Groves, M. A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity Commun Biol, 2021 Cited by DOI: 10.1038/s42003-021-02442-1PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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