6R8G

Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0006089	biological_process	lactate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase activity
B	0006089	biological_process	lactate metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase activity
C	0006089	biological_process	lactate metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase activity
D	0006089	biological_process	lactate metabolic process
D	0006090	biological_process	pyruvate metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue JUT A 401

Chain	Residue
A	LEU250
C	ASN188
C	VAL190
C	PHE195
C	MET200
A	PHE251
A	THR271
A	ALA272
A	LYS273
A	VAL282
A	PHE284
C	VAL161
C	VAL187

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site_id	AC2
Number of Residues	3
Details	binding site for residue NA A 402

Chain	Residue
A	ASP71
A	LYS111
A	TYR243

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site_id	AC3
Number of Residues	26
Details	binding site for residue NAD C 401

Chain	Residue
A	GLU65
A	HOH503
C	GLY10
C	GLN11
C	ILE12
C	TYR31
C	ASP32
C	VAL33
C	VAL34
C	THR76
C	ALA77
C	GLY78
C	GLN80
C	ILE97
C	VAL117
C	SER118
C	ASN119
C	LEU121
C	MET142
C	LEU146
C	HIS174
C	HOH501
C	HOH512
C	HOH514
C	HOH519
C	HOH524

---

site_id	AC4
Number of Residues	12
Details	binding site for residue JUT C 402

Chain	Residue
A	VAL161
A	ASN188
A	PHE195
A	MET200
C	VAL169
C	LEU250
C	PHE251
C	THR271
C	ALA272
C	LYS273
C	VAL282
C	PHE284

---

site_id	AC5
Number of Residues	14
Details	binding site for residue JUT D 401

Chain	Residue
B	VAL169
B	LEU250
B	PHE251
B	THR271
B	ALA272
B	LYS273
B	VAL282
B	PHE284
D	VAL161
D	VAL187
D	ASN188
D	VAL190
D	PHE195
D	MET200

---

site_id	AC6
Number of Residues	11
Details	binding site for residue JUT D 402

Chain	Residue
B	VAL161
B	VAL187
B	ASN188
B	VAL190
D	VAL169
D	THR271
D	ALA272
D	LYS273
D	HIS280
D	VAL282
D	PHE284

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