6R8G
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue JUT A 401 |
| Chain | Residue |
| A | LEU250 |
| C | ASN188 |
| C | VAL190 |
| C | PHE195 |
| C | MET200 |
| A | PHE251 |
| A | THR271 |
| A | ALA272 |
| A | LYS273 |
| A | VAL282 |
| A | PHE284 |
| C | VAL161 |
| C | VAL187 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | ASP71 |
| A | LYS111 |
| A | TYR243 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| A | GLU65 |
| A | HOH503 |
| C | GLY10 |
| C | GLN11 |
| C | ILE12 |
| C | TYR31 |
| C | ASP32 |
| C | VAL33 |
| C | VAL34 |
| C | THR76 |
| C | ALA77 |
| C | GLY78 |
| C | GLN80 |
| C | ILE97 |
| C | VAL117 |
| C | SER118 |
| C | ASN119 |
| C | LEU121 |
| C | MET142 |
| C | LEU146 |
| C | HIS174 |
| C | HOH501 |
| C | HOH512 |
| C | HOH514 |
| C | HOH519 |
| C | HOH524 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue JUT C 402 |
| Chain | Residue |
| A | VAL161 |
| A | ASN188 |
| A | PHE195 |
| A | MET200 |
| C | VAL169 |
| C | LEU250 |
| C | PHE251 |
| C | THR271 |
| C | ALA272 |
| C | LYS273 |
| C | VAL282 |
| C | PHE284 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue JUT D 401 |
| Chain | Residue |
| B | VAL169 |
| B | LEU250 |
| B | PHE251 |
| B | THR271 |
| B | ALA272 |
| B | LYS273 |
| B | VAL282 |
| B | PHE284 |
| D | VAL161 |
| D | VAL187 |
| D | ASN188 |
| D | VAL190 |
| D | PHE195 |
| D | MET200 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue JUT D 402 |
| Chain | Residue |
| B | VAL161 |
| B | VAL187 |
| B | ASN188 |
| B | VAL190 |
| D | VAL169 |
| D | THR271 |
| D | ALA272 |
| D | LYS273 |
| D | HIS280 |
| D | VAL282 |
| D | PHE284 |
