6R8G

Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Malate dehydrogenase	polymer	324	35362.9	4	UniProt (Q6VVP7)	Plasmodium falciparum
2	E, H, I, J (A, C, D)	4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine	non-polymer		212.2	4	Chemie (JUT)
3	F (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	G (C)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	1	Chemie (NAD)
5	K, L, M, N (A, B, C, D)	water	water		18.0	265	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 313 (UniProt: Q6VVP7)

PDB	External Database	Details
Ala 314	-	expression tag
Ala 315	-	expression tag
Ala 316	-	expression tag
Leu 317	-	expression tag
Glu 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	141451.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1535.3
All*	Total formula weight	142987.0

*Water molecules are not included.