6R7N

Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

Summary for 6R7N

• Entry DOI: 10.2210/pdb6r7n/pdb
• EMDB information: 4744
• Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, ZINC ION, ... (11 entities in total)
• Functional Keywords: cullin-ring e3 ligases (crls) cop9 signalosome (csn) deneddylation vhl tumour suppressor substrate receptor, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 367024.37

Authors

Faull, S.V.,Lau, A.M.C.,Martens, C.,Ahdash, Z.,Yebenes, H.,Schmidt, C.,Beuron, F.,Cronin, N.B.,Morris, E.P.,Politis, A. (deposition date: 2019-03-29, release date: 2019-08-28, Last modification date: 2019-09-04)

• Primary citation: Faull, S.V.,Lau, A.M.C.,Martens, C.,Ahdash, Z.,Hansen, K.,Yebenes, H.,Schmidt, C.,Beuron, F.,Cronin, N.B.,Morris, E.P.,Politis, A.; Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.; Nat Commun, 10:3814-3814, 2019; PubMed: 31444342; DOI: 10.1038/s41467-019-11772-y

Experimental method

ELECTRON MICROSCOPY (6.5 Å)