6R7N
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | COP9 signalosome complex subunit 1 | polymer | 491 | 55606.5 | 1 | UniProt (Q13098) Pfam (PF10602) Pfam (PF01399) Pfam (PF21151) | Homo sapiens (Human) | Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH |
| 2 | B (D) | COP9 signalosome complex subunit 4 | polymer | 406 | 46322.7 | 1 | UniProt (Q9BT78) Pfam (PF18420) Pfam (PF22241) Pfam (PF01399) | Homo sapiens (Human) | Signalosome subunit 4,JAB1-containing signalosome subunit 4 |
| 3 | C (H) | COP9 signalosome complex subunit 8 | polymer | 199 | 22258.3 | 1 | UniProt (Q99627) Pfam (PF10075) | Homo sapiens (Human) | Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8 |
| 4 | D (P) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | E (Q) | Elongin-C | polymer | 112 | 12485.1 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 6 | F (R) | RBX1 E3 ubiquitin-protein ligase | polymer | 86 | 10092.6 | 1 | Pfam (PF12678) UniProt (by SIFTS) (P62877) | Homo sapiens | |
| 7 | G (C) | COP9 signalosome complex subunit 3 | polymer | 401 | 45606.5 | 1 | UniProt (Q9UNS2) Pfam (PF22788) Pfam (PF01399) Pfam (PF21215) | Homo sapiens (Human) | Signalosome subunit 3,JAB1-containing signalosome subunit 3 |
| 8 | H (G) | CSN7B_HUMAN | polymer | 215 | 23944.4 | 1 | Pfam (PF22061) Pfam (PF01399) Pfam (PF18392) UniProt (by SIFTS) (Q9H9Q2) | Homo sapiens | |
| 9 | I (O) | Cullin-2 | polymer | 745 | 87098.9 | 1 | UniProt (Q13617) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (Human) | CUL-2 |
| 10 | J (B) | COP9 signalosome complex subunit 2 | polymer | 443 | 51664.6 | 1 | UniProt (P61201) Pfam (PF01399) | Homo sapiens (Human) | Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15 |
| 11 | K, L, M (R) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 366828.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 367024.4 |
