6R5G
C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1
Summary for 6R5G
Entry DOI | 10.2210/pdb6r5g/pdb |
NMR Information | BMRB: 34384 |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, ITSM (2 entities in total) |
Functional Keywords | shp-2 c-sh2 itsm sh2 domain pd-1 phosphotyrosine, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 14679.34 |
Authors | Marasco, M. (deposition date: 2019-03-25, release date: 2020-02-05, Last modification date: 2023-06-14) |
Primary citation | Marasco, M.,Berteotti, A.,Weyershaeuser, J.,Thorausch, N.,Sikorska, J.,Krausze, J.,Brandt, H.J.,Kirkpatrick, J.,Rios, P.,Schamel, W.W.,Kohn, M.,Carlomagno, T. Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6:eaay4458-eaay4458, 2020 Cited by PubMed: 32064351DOI: 10.1126/sciadv.aay4458 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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