6R4U

Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate

Summary for 6R4U

• Entry DOI: 10.2210/pdb6r4u/pdb
• Related: 6R4S 6R4T
• Descriptor: DNA primase small subunit, ZINC ION, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: primase, dna-dependent rna polymerase, atp, priming, replication
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 98904.01

Authors

Kilkenny, M.L.,Pellegrini, L. (deposition date: 2019-03-24, release date: 2019-09-11, Last modification date: 2024-01-24)

• Primary citation: Holzer, S.,Rzechorzek, N.J.,Short, I.R.,Jenkyn-Bedford, M.,Pellegrini, L.,Kilkenny, M.L.; Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.; Acs Chem.Biol., 14:1904-1912, 2019; PubMed: 31479243; DOI: 10.1021/acschembio.9b00367

Experimental method

X-RAY DIFFRACTION (2.2 Å)