6R2W
Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor
Summary for 6R2W
Entry DOI | 10.2210/pdb6r2w/pdb |
Descriptor | Coagulation factor VII, Tissue factor, alpha-D-xylopyranose-(1-3)-alpha-D-xylopyranose-(1-3)-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | trypsin-fold, protein-protein complex, hydrolase, coagulation factor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 70019.71 |
Authors | Sorensen, A.B.,Svensson, L.A.,Gandhi, P.S. (deposition date: 2019-03-19, release date: 2019-12-11, Last modification date: 2024-01-24) |
Primary citation | Sorensen, A.B.,Tuneew, I.,Svensson, L.A.,Persson, E.,Ostergaard, H.,Overgaard, M.T.,Olsen, O.H.,Gandhi, P.S. Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa. J.Biol.Chem., 295:517-528, 2020 Cited by PubMed: 31801825DOI: 10.1074/jbc.RA119.009183 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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