6R2S

The structure of Plasmodium vivax Duffy binding protein (PvDBP) bound to human antibody DB9

Summary for 6R2S

• Entry DOI: 10.2210/pdb6r2s/pdb
• Descriptor: Antibody DB9 light chain, Antibody DB9 heavy chain, Duffy receptor (3 entities in total)
• Functional Keywords: plasmodium vivax, invasion, broadly-neutralising human monoclonal antibody, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 90563.67

Authors

Barber, N.M.,Higgins, M.K. (deposition date: 2019-03-18, release date: 2019-03-27, Last modification date: 2024-01-24)

• Primary citation: Rawlinson, T.A.,Barber, N.M.,Mohring, F.,Cho, J.S.,Kosaisavee, V.,Gerard, S.F.,Alanine, D.G.W.,Labbe, G.M.,Elias, S.C.,Silk, S.E.,Quinkert, D.,Jin, J.,Marshall, J.M.,Payne, R.O.,Minassian, A.M.,Russell, B.,Renia, L.,Nosten, F.H.,Moon, R.W.,Higgins, M.K.,Draper, S.J.; Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody.; Nat Microbiol, 4:1497-1507, 2019; PubMed: 31133755; DOI: 10.1038/s41564-019-0462-1

Experimental method

X-RAY DIFFRACTION (3.04 Å)