6R1D

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 7d, co-crystallized

Summary for 6R1D

Entry DOI	10.2210/pdb6r1d/pdb
Descriptor	Cereblon isoform 4, ZINC ION, (phenylmethyl) ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamate, ... (4 entities in total)
Functional Keywords	proteolysis targeting chimera, protac, protein degradation, signaling protein
Biological source	Magnetospirillum gryphiswaldense MSR-1
Total number of polymer chains	2
Total formula weight	28034.44
Authors	Heim, C.,Hartmann, M.D. (deposition date: 2019-03-14, release date: 2019-08-07, Last modification date: 2024-01-24)
Primary citation	Heim, C.,Pliatsika, D.,Mousavizadeh, F.,Bar, K.,Hernandez Alvarez, B.,Giannis, A.,Hartmann, M.D. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J.Med.Chem., 62:6615-6629, 2019 Cited by PubMed: 31251063 DOI: 10.1021/acs.jmedchem.9b00454 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation