6R0E

Structure of F11TCR in complex with DR1 MHC Class II presenting PKYVKQNTLKLAT

This is a non-PDB format compatible entry.

Summary for 6R0E

• Entry DOI: 10.2210/pdb6r0e/pdb
• Related: 6EH6 6QZA 6QZC 6QZD
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Hemagglutinin, ... (9 entities in total)
• Functional Keywords: flu, mhc class ii, human, dr1, hla-dr1, 3d, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 95332.77

Authors

Rizkallah, P.J.,Greenshields-Watson, A.L. (deposition date: 2019-03-12, release date: 2020-07-15, Last modification date: 2024-11-20)

Primary citation

Greenshields-Watson, A.,Attaf, M.,MacLachlan, B.J.,Whalley, T.,Rius, C.,Wall, A.,Lloyd, A.,Hughes, H.,Strange, K.E.,Mason, G.H.,Schauenburg, A.J.,Hulin-Curtis, S.L.,Geary, J.,Chen, Y.,Lauder, S.N.,Smart, K.,Vijaykrishna, D.,Grau, M.L.,Shugay, M.,Andrews, R.,Dolton, G.,Rizkallah, P.J.,Gallimore, A.M.,Sewell, A.K.,Godkin, A.J.,Cole, D.K.
CD4+T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features.
Cell Rep, 32:107885-107885, 2020

PubMed Abstract: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8 T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4 T cells. Here, we investigate CD4 T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4 T cells in five HLA-DR1 subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies.

PubMed: 32668259
DOI: 10.1016/j.celrep.2020.107885

Experimental method

X-RAY DIFFRACTION (1.91 Å)