6QZR
14-3-3 sigma in complex with FOXO1 pT24 peptide
Summary for 6QZR
Entry DOI | 10.2210/pdb6qzr/pdb |
Related | 6qzs |
Descriptor | 14-3-3 protein sigma, Forkhead box protein O1, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | protein binding, 14-3-3, foxo1, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 16 |
Total formula weight | 239199.04 |
Authors | Ottmann, C.,Wolter, M.,Lau, R.A. (deposition date: 2019-03-12, release date: 2019-07-31, Last modification date: 2024-01-24) |
Primary citation | Saline, M.,Badertscher, L.,Wolter, M.,Lau, R.,Gunnarsson, A.,Jacso, T.,Norris, T.,Ottmann, C.,Snijder, A. AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294:13106-13116, 2019 Cited by PubMed: 31308176DOI: 10.1074/jbc.RA119.008649 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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